Hodgkin Lymphoma
Treatment for Hodgkin lymphoma with chemotherapy, radiation therapy, and immunotherapy options.
Hodgkin Lymphoma
Hematologic Malignancies
Overview
Treatment for Hodgkin lymphoma with chemotherapy, radiation therapy, and immunotherapy options.
When to Consult
After lymph node biopsy confirms Hodgkin lymphoma.
What to Bring
Biopsy report, PET-CT scan, bone marrow biopsy, and blood test results.
Risk Factors
Causes
Treatment Options
ABVD Chemotherapy
Standard first-line chemotherapy regimen combining doxorubicin (Adriamycin), bleomycin, vinblastine, and dacarbazine. Highly effective for early and advanced-stage Hodgkin lymphoma with cure rates exceeding 80%.
BEACOPP Chemotherapy
Intensive chemotherapy regimen (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) for high-risk advanced-stage disease. Higher cure rates but with increased toxicity.
Radiation Therapy
External beam radiation, often combined with chemotherapy (combined modality therapy). Used for early-stage disease, bulky tumors, or residual disease after chemotherapy. Advanced techniques minimize long-term side effects.
Stem Cell Transplantation
Autologous or allogeneic stem cell transplant for relapsed or refractory Hodgkin lymphoma. High-dose chemotherapy followed by stem cell infusion offers potential cure for patients who fail initial treatment.
Immunotherapy
Immune checkpoint inhibitors (nivolumab, pembrolizumab) and brentuximab vedotin (antibody-drug conjugate) for relapsed/refractory disease. Highly effective with durable responses, often used before stem cell transplant.
Targeted Therapy
Brentuximab vedotin targeting CD30 on Reed-Sternberg cells, and other targeted agents based on molecular profiling. Used alone or in combination with chemotherapy for improved outcomes.