Acute Lymphoblastic Leukemia
Comprehensive care for ALL, including intensive chemotherapy, targeted therapy, and stem cell transplantation.
Acute Lymphoblastic Leukemia
Hematologic Malignancies
Overview
Comprehensive care for ALL, including intensive chemotherapy, targeted therapy, and stem cell transplantation.
When to Consult
Upon diagnosis of ALL or suspicious blood test results.
What to Bring
CBC, peripheral smear, bone marrow biopsy, cytogenetic and molecular test reports.
Risk Factors
Causes
Treatment Options
Induction Chemotherapy
Intensive initial chemotherapy to achieve complete remission by destroying leukemia cells in bone marrow and blood. Multi-drug regimens including vincristine, prednisone, asparaginase, and anthracyclines administered over 4-6 weeks.
Consolidation Therapy
Post-remission intensive chemotherapy to eliminate any remaining leukemia cells and prevent relapse. High-dose methotrexate, cytarabine, and other agents given in cycles over several months.
Maintenance Therapy
Long-term lower-dose chemotherapy (typically 2-3 years) to prevent recurrence. Includes daily 6-mercaptopurine, weekly methotrexate, and periodic vincristine/prednisone pulses. Essential for sustained remission.
Stem Cell Transplantation
Allogeneic or autologous stem cell transplant for high-risk patients or those who relapse. Replaces diseased bone marrow with healthy stem cells after high-dose chemotherapy. Offers potential cure for selected patients.
Targeted Therapy
Precision treatments including imatinib, dasatinib for Philadelphia chromosome-positive ALL, blinatumomab (bispecific T-cell engager), and inotuzumab ozogamicin for relapsed/refractory disease based on genetic markers.
CAR-T Cell Therapy
Chimeric antigen receptor T-cell therapy, a form of immunotherapy where patient's T cells are genetically modified to attack leukemia cells. Highly effective for relapsed/refractory B-cell ALL, particularly in children and young adults.
Need Treatment?
Schedule a consultation to discuss treatment options for Acute Lymphoblastic Leukemia.