Gastric Cancer
Advanced treatment options for stomach cancer including surgery, chemotherapy, and targeted therapy.
Gastric Cancer
Solid Tumors
Overview
Advanced treatment options for stomach cancer including surgery, chemotherapy, and targeted therapy.
When to Consult
Upon diagnosis of gastric cancer or suspicious findings on endoscopy.
What to Bring
Endoscopy reports, biopsy results, CT scans, and previous treatment records.
Risk Factors
Causes
Treatment Options
Surgery (Gastrectomy)
Surgical removal of part (subtotal gastrectomy) or all (total gastrectomy) of the stomach, along with nearby lymph nodes. May include reconstruction of digestive tract. Primary treatment for resectable gastric cancer.
Chemotherapy
Systemic drug therapy using FLOT (5-FU, leucovorin, oxaliplatin, docetaxel), ECF/ECX, or DCF regimens. Used before surgery (neoadjuvant), after surgery (adjuvant), or as primary treatment for advanced/metastatic disease.
Targeted Therapy
Precision treatments including trastuzumab for HER2-positive gastric cancer, ramucirumab (anti-angiogenic), and other targeted agents based on molecular profiling (NTRK, MSI-H, PD-L1 status).
Immunotherapy
Immune checkpoint inhibitors (pembrolizumab, nivolumab) for advanced gastric cancer, particularly effective in PD-L1 positive tumors or microsatellite instability-high (MSI-H) cancers.
Radiation Therapy
External beam radiation, often combined with chemotherapy (chemoradiation), used as adjuvant therapy after surgery or for locally advanced unresectable tumors. Helps reduce local recurrence risk.
Palliative Procedures
Endoscopic stenting, bypass surgery, or feeding tube placement to relieve obstruction and maintain nutrition. Essential supportive care to improve quality of life in advanced disease.