Adrenal Cancer
Expert management of adrenal cancer including surgery (adrenalectomy), chemotherapy, targeted therapy, and hormone management.
Adrenal Cancer
Solid Tumors
Overview
Expert management of adrenal cancer including surgery (adrenalectomy), chemotherapy, targeted therapy, and hormone management.
When to Consult
Upon diagnosis of adrenal mass, hormonal abnormalities, or confirmed adrenal cancer diagnosis.
What to Bring
CT/MRI scans, hormone level tests (cortisol, aldosterone, catecholamines), biopsy reports, and endocrine history.
Risk Factors
Causes
Treatment Options
Adrenalectomy
Surgical removal of the affected adrenal gland, often with surrounding tissues and lymph nodes. Can be performed via open surgery or minimally invasive laparoscopic/robotic techniques. Primary treatment for resectable adrenal cancer.
Mitotane
Adrenocorticolytic chemotherapy drug that specifically targets adrenal cells. Used as adjuvant therapy after surgery to reduce recurrence risk, or for advanced/metastatic disease. Requires careful monitoring of hormone levels.
Chemotherapy
Systemic drug therapy using EDP (etoposide, doxorubicin, cisplatin) or other platinum-based regimens for advanced or metastatic adrenal cancer. Often combined with mitotane for improved outcomes.
Targeted Therapy
Precision treatments including sunitinib, pazopanib (tyrosine kinase inhibitors) for advanced adrenal cortical carcinoma. Based on molecular profiling and genetic mutations found in tumor cells.
Hormone Management
Medications to control excess hormone production (cortisol, aldosterone, catecholamines) before and after surgery. Essential for managing symptoms and preventing complications from hormonal imbalances.
Radiation Therapy
External beam radiation for local tumor control, treatment of metastases, or palliative care. Less commonly used as primary treatment but may be beneficial for specific cases or symptom management.